At the time of writing, the Reds are fourth in the Eastern Conference league standings, four points adrift of the table-topping Union, but with three games in hand.
One of those games in hand for Toronto took place the Wednesday night prior to hosting Philadelphia, when they went down to a 2-0 loss on the road at Atlanta United.
Both these teams had good wins last weekend, with the Reds coming away from Orlando City with a 2-0 victory thanks to goals from Jonathan Osorio and substitute Jay Chapman.
The Union are in good form of late, having taken 10 points from their last four games, culminating in a comprehensive 6-1 win on home-turf against New England Revolution last time out.
The win saw two goals from Sergio Santos within 10 minutes of him coming off the bench as a second-half substitute and one each from Jack Elliott, Ilsinho, Kacper Przybyłko and David Accam.
Toronto FC vs Philadelphia Union Betting Lines & Prediction
With Toronto FC facing a tough road trip to Atlanta just a few days before this game with Philadelphia, predictions are a risky business.
However, the Reds have been strong on home-turf this season, so the tip is for another Toronto win on the Match Result betting at odds of +100 with bet365. The draw can be backed at +280 with bet365, with Philadelphia available at +245 with 888Sport.
A Correct Score bet of 2-1 to Toronto is on offer at +750 with bet365, while Alejandro Pozuelo is +195 with 888Sport in the Anytime Goalscorer market.